A diagnostic challenge in an individual with Paracoccidioidomycosis during hospitalization in times of COVID-19

Paracoccidioidomycosis (PCM) is a deep fungal infection, endemic with considerable morbidity in South America, whose first symptoms can occur in the oral cavity. A 47-year-old male patient, leucoderma, living on the streets, presenting dyspnea, pain during the speech, and dysphagia, was referred for admission to the ICU for suspected COVID-19 infection. The intensive care physician\u27s evaluation revealed a tongue lesion with suspected carcinoma. By dentist investigation, was observed the presence of moriform lesions with high borders delimitation in the tongue. Also, granulomatous ulcers with irregular texture, suggesting moriform stomatitis, the chest tomography revealed diffuse thickening of the bronchial walls, indicating chronic bronchopathy with discrete centrilobular nodules, sometimes confluent. Incisional tongue biopsy associated with lung imaging confirmed the diagnosis of PCM, and the patient was referred to the referral center for the treatment of fungal diseases. The involvement of the oral environment as a region to the appearance of detectable first symptoms of PCM suggests the need for the oral evaluation by a specialist as a diagnostic tool

Basal cell carcinoma - epidemiology, pathogenesis, pathology, and association with inflammation biomarkers. A review

Basal cell carcinoma is the most common malignant neoplasm in humans, with low mortality, high morbidity, and exposure to solar radiation (UVB and UVA) is the most critical risk factor. Ultraviolet B rays generate mutagenic photoproducts in DNA and mutations in important genes regulating cellular functions, such as the tumor suppressor gene TP53. Ultraviolet A rays generate cytotoxic and mutagenic free radicals, potentiating the effects of UVB rays.. There is current evidence to support the role of inflammatory biomarkers related to tumorigenesis of basal cell carcinoma

Epidermodysplasia Verruciformis acquired in an HIV-positive patient

The disease epidermodysplasia verruciformis is a rare genodermatosis, autosomal recessive in most cases, characterized by susceptibility to infection by types of HPV of the genus β (EV-HPV) that do not occur in immunocompetent clinics. With the increased survival of immunosuppressed patients, especially with AIDS, a form of the disease called epidermodysplasia verruciformis acquired from a clinician similar to the genetic disease has been reduced, but challenging to manage, since an antiretroviral therapy leads to a cutaneous one, making patients more resistant to any treatment modality

Comparação entre a hidroxiapatita porosa de coral e o enxerto ósseo autógeno em coelhos Comparison between coralline porus hidroxyapatite and osseous xenograft in rabbits

O objetivo da pesquisa é a utilização da hidroxiapatita porosa de coral, como um xenoenxerto ósseo. Utilizou-se onze coelhos da raça Nova Zelândia, nos quais fez-se defeito padrão nas metáfises femorais distais. Nesses locais praticou-se o implante de hidroxiapatita porosa de coral ou enxerto ósseo autógeno. Fez-se estudo clínico, macroscópico, exames radiológicos e histológicos em intervalos de duas, quatro e doze semanas. Os resultados comparativos foram similares enter dois tipos de implantes. Concluiu-se que a hidroxiapatita porosa de coral é um substituto adequado para enxertos ósseos autógenos em coelhos.<br>The purpose is to utilize coralline porous hydroxyapatite as osseous xenograft. It was utilized eleven New Zeland rabbits, wich it made pattern defect in the distal femoral mataphise. In this place was used coralline porous hidroxyapatite or autogenous graft. It was made clinical, macroscopic, radiologic and histologic study, with interval of two, four and twelve weeks. The comparatives results was similaries between the two implants types. It was concluded taht coralline porous hidroxyapatite is appropriate replacement for osseos autogenous grafts in rabbits

Xantoma plano difuso normolipêmico idiopático com hiperesplenismo

O xantoma plano difuso normolipêmico é doença rara, do grupo das histiocitoses, caracterizada pelo aparecimento de placas amareladas ou amarelo-alaranjadas, distribuídas simetricamente na pele e geralmente acompanhadas por xantelasma. Acomete principalmente adultos, podendo ou não apresentar alterações discretas dos lípides séricos. Relata-se o caso de uma paciente do sexo feminino, de 85 anos, há um ano com extensas placas amarelo-alaranjadas no tronco e abdome, assintomáticas. Os exames laboratoriais não demonstraram aumento dos lípides séricos, nem ocorrência de desordens retículo-endoteliais

A Basal cell carcinoma in the labial filter: Surgical treatment and reconstruction with bilateral perialar advancement flap in ascending

The bilateral perialar advancement flap in ascending is a good option for restoring complex upper lip defects. We report a patient presenting with a basal cell carcinoma in the upper lip filter, submitted to reconstruction with bilateral perialar advancement flap in ascending: a technique that is easy to perform, under local anesthesia and with excellent esthetic results